Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 10/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | RPA1 | P27694 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ACR | P10323 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18558170 | 0.94 | HDAC3 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18558568 | 0.82 | HDAC3 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18557797 | 0.82 | HDAC3 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18558180 | 0.80 | MAPK1 (0.38) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18558067 | 0.80 | RAB9A (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19362668 | 0.80 | HDAC3 (0.37) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18558616 | 0.79 | MAPK1 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18558628 | 0.79 | HDAC3 (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18558392 | 0.79 | MAPK1 (0.37) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18558655 | 0.78 | HDAC3 (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932313-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-04-03 | — | — | US | disclosed |
| US-20170267643-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2017-09-21 | — | — | US | disclosed |
| US-9580388-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267643-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | ATP5F1A, ATP5F1D, ATP5ME | HDAC3 3431/4885HDAC4 1902/4885HDAC1 1753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.