Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 9/20 | 0.59 |
| ▸ | JAK3 | P52333 | 7/20 | 0.59 |
| ▸ | TYK2 | P29597 | 2/20 | 0.57 |
| ▸ | JAK1 | P23458 | 4/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 2/20 | 0.53 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16204478 | 0.95 | EGFR (0.62) | EGFRPLK4JAK2JAK3TYK2 | |
| SCHEMBL13859328 | 0.91 | EGFR (0.58) | EGFRPLK4JAK2JAK3TYK2 | |
| SCHEMBL13859327 | 0.91 | EGFR (0.58) | EGFRPLK4JAK2JAK3TYK2 | |
| SCHEMBL18559719 | 0.91 | EGFR (0.58) | EGFRPLK4JAK2JAK3TYK2 | |
| SCHEMBL13977853 | 0.87 | PLK4 (0.60) | EGFRPLK4JAK2JAK3TYK2 | |
| SCHEMBL13859449 | 0.84 | JAK3 (0.77) | EGFRPLK4JAK2JAK3TYK2 | |
| SCHEMBL13859528 | 0.77 | AURKA (0.50) | EGFRPLK4JAK2JAK3TYK2 | |
| SCHEMBL13859526 | 0.77 | AURKA (0.50) | EGFRPLK4JAK2JAK3TYK2 | |
| SCHEMBL17059694 | 0.77 | EGFR (1.00) | EGFRJAK2JAK3TYK2JAK1 | |
| SCHEMBL10127802 | 0.76 | EGFR (0.87) | EGFRJAK2JAK3TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580427-B2 | Kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-28 | — | — | US | disclosed |