Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | JAK2 | O60674 | 9/20 | 0.59 |
| ▸ | JAK3 | P52333 | 6/20 | 0.59 |
| ▸ | JAK1 | P23458 | 3/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 3/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18559720 | 0.87 | EGFR (0.62) | PLK4EGFRJAK2JAK3JAK1 | |
| SCHEMBL16204478 | 0.87 | EGFR (0.62) | PLK4EGFRJAK2JAK3JAK1 | |
| SCHEMBL13859328 | 0.84 | EGFR (0.58) | PLK4EGFRJAK2JAK3JAK1 | |
| SCHEMBL18559719 | 0.84 | EGFR (0.58) | PLK4EGFRJAK2JAK3JAK1 | |
| SCHEMBL13859327 | 0.84 | EGFR (0.58) | PLK4EGFRJAK2JAK3JAK1 | |
| SCHEMBL13859449 | 0.84 | JAK3 (0.77) | PLK4EGFRJAK2JAK3JAK1 | |
| SCHEMBL17059694 | 0.74 | EGFR (1.00) | EGFRJAK2JAK3JAK1TYK2 | |
| SCHEMBL28876010 | 0.74 | JAK2 (0.71) | PLK4EGFRJAK2JAK3JAK1 | |
| SCHEMBL29813539 | 0.74 | JAK2 (0.71) | PLK4EGFRJAK2JAK3JAK1 | |
| SCHEMBL16295705 | 0.72 | PLK4 (0.72) | PLK4EGFRJAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158843-A2 | KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-22 | — | — | WO | disclosed |