Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513823 | 0.84 | HRH3 (0.37) | HRH3HDAC4TRPV4TRPM8HCAR2 | |
| SCHEMBL512262 | 0.73 | HRH3 (0.35) | HRH3HDAC4TRPV4DGAT1 | |
| SCHEMBL512837 | 0.69 | UGT1A1 (0.35) | HRH3HDAC4TRPV4TRPM8P2RX3 | |
| SCHEMBL322678 | 0.68 | HDAC4 (0.34) | HRH3HDAC4TRPV4TRPM8KCNH2 | |
| SCHEMBL512759 | 0.67 | HRH3 (0.42) | HRH3HDAC4TRPV4TRPM8DGAT1 | |
| SCHEMBL25920490 | 0.65 | HRH3 (0.47) | HRH3HDAC4TRPV4HCAR2DGAT1 | |
| SCHEMBL30455383 | 0.65 | MEN1 (0.39) | HRH3HDAC4 | |
| SCHEMBL25647431 | 0.64 | HTT (0.50) | HRH3HDAC4TRPV4DGAT1KDM1A | |
| SCHEMBL28935850 | 0.64 | TRPV4 (0.46) | HRH3HDAC4TRPV4HCAR2DGAT1 | |
| SCHEMBL20010524 | 0.63 | ESR2 (0.46) | HRH3HDAC4TRPV4TRPM8HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668168-B1 | COMPOUNDS FOR THE REDUCTION OF ß-AMYLOID PRODUCTION | BRISTOL MYERS SQUIBB CO (US) | 2017-03-01 | — | — | EP | disclosed |