Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854872 | 0.81 | KMT2A (0.55) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL4715407 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL5044430 | 0.78 | KMT2A (0.52) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL4714622 | 0.77 | TSHR (0.56) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL1853154 | 0.76 | KMT2A (0.66) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL1853562 | 0.74 | KMT2A (0.50) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL1855668 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL4711870 | 0.73 | HTT (0.52) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL4019037 | 0.73 | HTT (0.51) | SMN1; SMN2KMT2AHTTTSHRMEN1 | |
| SCHEMBL4715831 | 0.72 | TSHR (0.60) | SMN1; SMN2KMT2AHTTTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |
| EP-1986637-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | Laboratoires Serono SA (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093557-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | LABORATOIRES SERONO S.A. (CH) | 2007-08-23 | — | — | WO | disclosed |