Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855668 | 0.85 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL4021235 | 0.82 | SMN1; SMN2 (0.45) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL1851100 | 0.81 | SMN1; SMN2 (0.44) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL1854872 | 0.79 | KMT2A (0.55) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL4021233 | 0.78 | SMN1; SMN2 (0.41) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL1856185 | 0.78 | SMN1; SMN2 (0.54) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL4715407 | 0.77 | SMN1; SMN2 (0.69) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL5048888 | 0.77 | SMN1; SMN2 (0.53) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL1853154 | 0.75 | KMT2A (0.66) | KMT2ASMN1; SMN2MEN1HTTTSHR | |
| SCHEMBL6719223 | 0.74 | SMN1; SMN2 (0.49) | KMT2ASMN1; SMN2MEN1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |