SCHEMBL18562147

SCHEMBL18562147

Ic1ccc2cnc(I)cc2c1

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.45
NOS1 P29475 1/20 0.41
CYP1A2 P05177 1/20 0.31
CYP2A6 P11509 1/20 0.31
PDPK1 O15530 1/20 0.31
CASP3 P42574 1/20 0.30
SENP8 Q96LD8 1/20 0.30
SENP7 Q9BQF6 1/20 0.30
SENP6 Q9GZR1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18574576 0.91 NOS1 (0.41) MAPTNOS1CYP1A2CYP2A6PDPK1
SCHEMBL18574471 0.78 CYP1A2 (0.52) CYP1A2CYP2A6
SCHEMBL19001524 0.78 CYP1A2 (0.57) MAPTNOS1CYP1A2CYP2A6
SCHEMBL23060848 0.77 MIF (0.31)
SCHEMBL4238751 0.76 CYP1A2 (0.54) MAPTCYP1A2CYP2A6PDPK1
SCHEMBL6561374 0.74 NOS1 (0.42) MAPTNOS1CYP1A2CYP2A6
SCHEMBL30388219 0.74 NOS1 (0.42) MAPTNOS1CYP1A2CYP2A6
SCHEMBL19001492 0.73 NOS1 (0.45) MAPTNOS1
SCHEMBL9422180 0.72 NOS1 (0.41) MAPTNOS1CYP1A2CYP2A6
SCHEMBL19230462 0.72 NOS1 (0.41) MAPTNOS1CYP1A2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170133599-A1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2017-05-11 US disclosed
EP-2861604-B1 MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES GILEAD SCIENCES INC (US) 2017-03-01 EP disclosed