SCHEMBL18563045

SCHEMBL18563045

Cc1c(N=C=Nc2ccccc2)cccc1N=C=Nc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.54
MIF P14174 1/20 0.43
ALDH1A1 P00352 2/20 0.35
NOS3 P29474 2/20 0.32
NOS1 P29475 2/20 0.32
TRPA1 O75762 1/20 0.32
FTO Q9C0B1 1/20 0.32
MAPT P10636 1/20 0.32
TDP1 Q9NUW8 2/20 0.31
ABCB11 O95342 1/20 0.31
NR3C1 P04150 1/20 0.31
CYP1A2 P05177 1/20 0.31
ADRA2A P08913 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
ADRA2C P18825 1/20 0.31
MAOA P21397 1/20 0.31
DRD1 P21728 1/20 0.31
SLC6A4 P31645 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27841313 0.90 CYP3A4 (0.44) CYP3A4MIFALDH1A1TRPA1MAPT
SCHEMBL8401752 0.83 MIF (0.43) CYP3A4MIFALDH1A1NOS3NOS1
SCHEMBL508210 0.83 MIF (0.43) CYP3A4MIFALDH1A1NOS3NOS1
SCHEMBL156948 0.81 MIF (0.60) MIFALDH1A1NOS3NOS1TRPA1
SCHEMBL25341986 0.78 CYP3A4 (0.48) CYP3A4ALDH1A1TRPA1MAPTTDP1
SCHEMBL29409677 0.78 CYP3A4 (0.48) CYP3A4ALDH1A1TRPA1MAPTTDP1
SCHEMBL1416730 0.77 CYP3A4 (0.52) CYP3A4ALDH1A1TRPA1MAPTTDP1
SCHEMBL508209 0.77 MIF (0.46) MIFALDH1A1NOS3NOS1FTO
SCHEMBL800487 0.77 MIF (0.50) MIFALDH1A1NOS3NOS1TRPA1
SCHEMBL2047233 0.76 TSHR (0.47) CYP3A4MIFALDH1A1TRPA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9982083-B2 Polyiso-urea BASF SE (DE) 2018-05-29 US disclosed
US-20170058075-A1 POLYISO-UREA BASF SE (DE) 2017-03-02 US disclosed