SCHEMBL18563333

SCHEMBL18563333

c1ccc2c(c1)Oc1ccc(-c3ccc(Nc4ccc5c(c4)oc4ccccc45)cc3)cc1O2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 9/20 0.44
MEN1 O00255 8/20 0.44
SMN1; SMN2 Q16637 8/20 0.44
NPC1 O15118 8/20 0.44
RAB9A P51151 8/20 0.44
GAA P10253 4/20 0.44
LMNA P02545 4/20 0.44
HTT P42858 3/20 0.44
ALDH1A1 P00352 7/20 0.42
MAPT P10636 6/20 0.42
HPGD P15428 5/20 0.42
KDM4E B2RXH2 5/20 0.42
HSD17B10 Q99714 4/20 0.41
ATM Q13315 1/20 0.41
TP53 P04637 4/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18583755 0.90 KMT2A (0.47) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL17657674 0.87 NPC1 (0.51) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL21086890 0.87 KMT2A (0.53) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL22154912 0.84 MEN1 (0.47) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL12476671 0.84 KMT2A (0.50) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL21039222 0.84 KMT2A (0.50) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL29514982 0.84 KMT2A (0.50) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL29918552 0.84 KMT2A (0.50) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL30386326 0.84 KMT2A (0.50) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL18570108 0.84 KMT2A (0.37) KMT2AMEN1SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10361373-B2 Condensed-cyclic compound and organic light emitting device comprising the same SAMSUNG DISPLAY CO., LTD. (KR) 2019-07-23 US disclosed
US-20170062720-A1 CONDENSED-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2017-03-02 US disclosed
US-20170062720-A1 CONDENSED-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2017-03-02 US disclosed
EP-3135673-A2 CONDENSED-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME Samsung Display Co., Ltd. (KR) 2017-03-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170062720-A1 CONDENSED-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME LRRK2, SLC18A1, CCNT1 KMT2A 841/4885MEN1 2312/4885SMN1; SMN2 2402/4885
US-10361373-B2 Condensed-cyclic compound and organic light emitting device comprising the same LRRK2, SLC18A1, CCNT1 KMT2A 841/4885MEN1 2312/4885SMN1; SMN2 2402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.