SLC18A1

Chromaffin granule amine transporter · P54219 · SLC18A1 on Sugi Atlas →

756 patent compounds predicted against SLC18A1, 695 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Reserpine (SCHEMBL2589)	1.00	1/20
Isoreserpine (SCHEMBL731599)	1.00	1/20
Reserpine (SCHEMBL1172973)	1.00	1/20
Reserpine (SCHEMBL4562878)	1.00	1/20
Reserpine (SCHEMBL5372164)	1.00	1/20
Reserpine (SCHEMBL5372168)	1.00	1/20
Reserpine (SCHEMBL8262666)	1.00	1/20
Reserpine (SCHEMBL12732449)	1.00	1/20
Reserpine (SCHEMBL14379427)	1.00	1/20
Reserpine (SCHEMBL15385127)	1.00	1/20
Reserpine (SCHEMBL20402680)	1.00	1/20
Reserpine (SCHEMBL22002247)	1.00	1/20
Reserpine (SCHEMBL241313)	0.99	1/20
Reserpine (SCHEMBL1579009)	0.99	1/20
Reserpine (SCHEMBL2699112)	0.99	1/20
Reserpine (SCHEMBL2770274)	0.99	1/20
Reserpine (SCHEMBL4773721)	0.99	1/20
Reserpine (SCHEMBL6164539)	0.99	1/20
Reserpine (SCHEMBL7214249)	0.99	1/20
Reserpine (SCHEMBL8743761)	0.99	1/20

Clinical trials — most relevant to SLC18A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Weight Loss Study: Genetics and Response to Naltrexone/Bupropion	PHASE4	RECRUITING
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD	PHASE3	COMPLETED
New Treatment for Alcohol and Nicotine Dependence	PHASE2/PHASE3	COMPLETED
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room	PHASE2/PHASE3	COMPLETED
Xenazine in Late Dyskinetic Syndrome With Neuroleptics	PHASE3	COMPLETED
18FluoroLDOPA PET Imaging for the Detection and Localization of Focal Congenital Hyperinsulinism	PHASE2	RECRUITING
18F-FDOPA PET in Neuroendocrine Tumours	nan	NO_LONGER_AVAILABLE
DaTSCAN Brain Scintigraphy and Psychotropic Treatments: Influence on Radiotracer Binding	nan	COMPLETED
TRANSEURO Open Label Transplant Study in Parkinson's Disease	nan	COMPLETED
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging	nan	COMPLETED
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
POTS NET mRNA Functional Correlation With NET Activity	nan	ACTIVE_NOT_RECRUITING
I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers	nan	COMPLETED
Stem Cell Study of Genetics and Drug Addiction	nan	COMPLETED
Autonomic Function in Patients With COPD	nan	COMPLETED
PET Whole Body Distribution Studies Using [11C]CUMI	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Study of Chediak-Higashi Syndrome	nan	RECRUITING
Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery	nan	RECRUITING
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Blood Sampling for Neurochemical and Genetic Testing	nan	COMPLETED
Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus Monotherapy	nan	NOT_YET_RECRUITING
Neuropathological Changes of the Intestinal Wall in Patients With Bowel Evacuation Disorders	nan	RECRUITING
PET-MRI F-DOPA Activity in the Mesocorticolimbic System and Depressive Symptoms in the Prediction of Treatment Compatibility	nan	UNKNOWN
The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome	nan	UNKNOWN
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia	nan	COMPLETED
Molecular Epidemiology of Parkinson's Disease	nan	COMPLETED
Childhood Adversity, Genetic Polymorphisms and Stress in First Onset Major Depression	nan	COMPLETED
Can Acupuncture Treat Post-stroke Depression?	nan	COMPLETED
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC18A1 binder may also engage these)

Protein	Name	Similarity
Q01818	—	1.000	Q01818 →
Q8R090	—	0.998	Q8R090 →
Q27963	—	0.989	Q27963 →
Q8BRU6	—	0.980	Q8BRU6 →
Q01827	—	0.977	Q01827 →
SLC18A2	Synaptic vesicular amine transporter	0.972	landscape →
Q8NHS3	—	0.964	Q8NHS3 →
F1NCD6	—	0.962	F1NCD6 →
Q58CV5	—	0.961	Q58CV5 →
B0JZE1	—	0.960	B0JZE1 →
Q9WU81	—	0.959	Q9WU81 →
Q8BH31	—	0.958	Q8BH31 →
Q8TED4	—	0.956	Q8TED4 →
Q9DA75	—	0.956	Q9DA75 →
Q9JHI9	—	0.955	Q9JHI9 →
Q7SY29	—	0.955	Q7SY29 →
Q80T22	—	0.954	Q80T22 →
Q5TF39	—	0.952	Q5TF39 →
Q923U9	—	0.952	Q923U9 →
Q8NA29	—	0.952	Q8NA29 →
Q6DEJ6	—	0.952	Q6DEJ6 →
Q8R070	—	0.951	Q8R070 →
Q5ZIT9	—	0.950	Q5ZIT9 →
Q0IHM1	—	0.950	Q0IHM1 →
SLC40A1	Ferroportin	0.949	landscape →
Q17QZ3	—	0.949	Q17QZ3 →
E2RFJ3	—	0.947	E2RFJ3 →
Q1JP63	—	0.947	Q1JP63 →
Q9DC37	—	0.947	Q9DC37 →
Q9I9R3	—	0.947	Q9I9R3 →