Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15447650 | 0.89 | MAPT (0.52) | MAPTPTPN5SMN1; SMN2LMNARXRA | |
| SCHEMBL17299140 | 0.89 | MAPT (0.52) | MAPTPTPN5SMN1; SMN2LMNARXRA | |
| SCHEMBL17299139 | 0.84 | KDM4E (0.53) | MAPTNPC1RAB9A | |
| SCHEMBL15447648 | 0.84 | KDM4E (0.53) | MAPTNPC1RAB9A | |
| SCHEMBL8264165 | 0.80 | PPARG (0.51) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL18563474 | 0.79 | GAA (0.53) | MAPTPTPN5LMNARXRARXRB | |
| SCHEMBL7733929 | 0.78 | MAPT (0.66) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL15447676 | 0.76 | CYP1A2 (0.69) | MAPTPTPN5RXRARXRBRXRG | |
| SCHEMBL15447706 | 0.76 | CYP1A2 (0.69) | MAPTPTPN5RXRARXRBRXRG | |
| SCHEMBL17299142 | 0.76 | CYP1A2 (0.69) | MAPTPTPN5RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861604-B1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2017-03-01 | — | — | EP | disclosed |