Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312815 | 1.00 | ALDH1A1 (0.56) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1858866 | 1.00 | ALDH1A1 (0.56) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1858819 | 0.85 | ALDH1A1 (0.51) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4737115 | 0.83 | S1PR1 (0.63) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL11338689 | 0.82 | ALDH1A1 (0.56) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27619399 | 0.82 | ALDH1A1 (0.56) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6820556 | 0.82 | ALDH1A1 (0.56) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6805181 | 0.80 | MAPT (0.54) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6805184 | 0.80 | ALDH1A1 (0.54) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12117878 | 0.80 | NPC1 (0.54) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |
| US-7592477-B2 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases (PTPs) | LABORATOIRES SERONO SA (CH) | 2009-09-22 | — | — | US | disclosed |
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | APPLIED RESEARCH SYSTEMS ARS (NL) | 2005-06-09 | — | — | US | disclosed |
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | PTPRS, PTPA, PTPMT1 | ALDH1A1 3733/4885NPC1 2939/4885MAPT 4575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.