Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850349 | 0.95 | TSHR (0.47) | TSHRHSD17B10MAPTKDM4ETDP1 | |
| SCHEMBL22866726 | 0.86 | TSHR (0.48) | TSHRHSD17B10MAPTKDM4ETDP1 | |
| SCHEMBL29561227 | 0.86 | TSHR (0.48) | TSHRHSD17B10MAPTKDM4ETDP1 | |
| SCHEMBL18264005 | 0.86 | HSD17B10 (0.52) | TSHRHSD17B10MAPTKDM4ETDP1 | |
| SCHEMBL1851538 | 0.85 | DAO (0.46) | TSHRALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL17434348 | 0.84 | TSHR (0.51) | TSHRHSD17B10MAPTKDM4ETDP1 | |
| SCHEMBL18264008 | 0.82 | HSD17B10 (0.49) | TSHRHSD17B10MAPTKDM4ETDP1 | |
| SCHEMBL18264010 | 0.80 | HSD17B10 (0.47) | TSHRHSD17B10MAPTKDM4ETDP1 | |
| SCHEMBL1855350 | 0.80 | HSD17B10 (0.47) | TSHRHSD17B10MAPTKDM4ETDP1 | |
| SCHEMBL30765089 | 0.78 | JAK2 (0.50) | TSHRHSD17B10MAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |