Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.36 |
| ▸ | JUN | P05412 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | ATF1 | P18846 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15096933 | 0.77 | SYK (0.60) | SYKIRAK4IRAK1NFKB1JUN | |
| SCHEMBL15093593 | 0.75 | SYK (0.61) | SYKIRAK4IRAK1NFKB1JUN | |
| SCHEMBL15093626 | 0.74 | SYK (0.61) | SYKIRAK4NFKB1NFKB2RELA | |
| SCHEMBL15093395 | 0.73 | SYK (0.52) | SYKIRAK4IRAK1NFKB1JUN | |
| SCHEMBL358315 | 0.73 | SYK (0.52) | SYKIRAK4IRAK1NFKB1JUN | |
| SCHEMBL15093623 | 0.72 | SYK (0.58) | SYKIRAK4NFKB1NFKB2RELA | |
| SCHEMBL15093609 | 0.71 | SYK (0.61) | SYK | |
| SCHEMBL359245 | 0.71 | SYK (0.60) | SYK | |
| SCHEMBL15093707 | 0.70 | SYK (0.64) | SYKIRAK4IRAK1NFKB1JUN | |
| SCHEMBL359875 | 0.70 | ALDH1A1 (0.54) | SYKIRAK4IRAK1NFKB1ATF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2802590-B1 | THIENOPYRIMIDINE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |