Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 4/20 | 0.35 |
| ▸ | CDK8 | P49336 | 4/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | MDH2 | P40926 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14731537 | 0.88 | CCNB2 (0.44) | MAPKAPK2CCNB2CDK1CCNB1MDH2 | |
| SCHEMBL14731397 | 0.88 | KDM4E (0.40) | MAPKAPK2NR1H4CCNB2CDK1CCNB1 | |
| SCHEMBL14731482 | 0.87 | MAPKAPK2 (0.41) | MAPKAPK2TTKNR1H4KDM4EGAA | |
| SCHEMBL18567380 | 0.87 | MAPKAPK2 (0.41) | MAPKAPK2TLR8TLR7TLR9CSNK1D | |
| SCHEMBL14731476 | 0.86 | PARP1 (0.42) | MAPKAPK2TLR8TLR7TLR9KDM4E | |
| SCHEMBL14731483 | 0.86 | RAB9A (0.39) | MAPKAPK2TLR8TLR7TLR9 | |
| SCHEMBL18567602 | 0.85 | MAPKAPK2 (0.44) | MAPKAPK2TLR8TLR7TLR9CSNK1D | |
| SCHEMBL14731478 | 0.85 | RAB9A (0.42) | TLR8TLR7TLR9 | |
| SCHEMBL14731538 | 0.85 | RAB9A (0.45) | MAPKAPK2TLR8TLR7TLR9CHEK1 | |
| SCHEMBL14731484 | 0.84 | SMYD3 (0.49) | TLR8TLR7TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748167-B1 | HEPATITIS C INHIBITOR COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2017-03-01 | — | — | EP | disclosed |