Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64106 | 0.86 | NR3C2 (0.44) | NR3C2SMN1; SMN2ABCB1THRBCCNA2 | |
| SCHEMBL1861410 | 0.86 | P4HTM (0.45) | NR3C2ABCB1MAPTHDAC1ROCK2 | |
| SCHEMBL64524 | 0.85 | ALDH1A1 (0.47) | NR3C2SMN1; SMN2ABCB1THRBCCNA2 | |
| SCHEMBL1859162 | 0.84 | ABCB1 (0.44) | NR3C2SMN1; SMN2ABCB1MTNR1AMTNR1B | |
| SCHEMBL64528 | 0.84 | P4HTM (0.53) | NR3C2ABCB1ROCK2ROCK1 | |
| SCHEMBL64697 | 0.84 | ABCB1 (0.46) | NR3C2SMN1; SMN2ABCB1HDAC1ROCK2 | |
| SCHEMBL64096 | 0.83 | KCNQ3 (0.42) | NR3C2SMN1; SMN2ABCB1MAPTROCK2 | |
| SCHEMBL63796 | 0.82 | NR3C2 (0.41) | NR3C2SMN1; SMN2ABCB1MTNR1BTHRB | |
| SCHEMBL63192 | 0.81 | ABCB1 (0.43) | NR3C2SMN1; SMN2ABCB1MAPTROCK2 | |
| SCHEMBL63836 | 0.81 | NR3C2 (0.49) | NR3C2SMN1; SMN2ABCB1THRBCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-B1 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2011-05-25 | — | — | EP | claimed |