Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.50 |
| ▸ | ACACB | O00763 | 11/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | ACACA | Q13085 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21434685 | 0.88 | PRKAB2 (0.47) | PARP10PARP15ACACB | |
| SCHEMBL8903105 | 0.84 | CA12 (0.55) | PARP10PARP15ACACBPARP2SCN9A | |
| SCHEMBL1854146 | 0.84 | PARP10 (0.51) | PARP10PARP15ACACBPARP2SCN9A | |
| SCHEMBL15969380 | 0.84 | PARP10 (0.50) | PARP10PARP15ACACBPARP2 | |
| SCHEMBL3225627 | 0.83 | PARP10 (0.67) | PARP10PARP15ACACBPARP2SCN9A | |
| SCHEMBL1856415 | 0.83 | PARP10 (0.64) | PARP10PARP15ACACBPARP2SCN9A | |
| SCHEMBL26126220 | 0.83 | PARP10 (0.53) | PARP10PARP15ACACBPARP2SCN9A | |
| SCHEMBL6301208 | 0.81 | PARP10 (0.56) | PARP10PARP15PARP2 | |
| SCHEMBL21447016 | 0.81 | TDP1 (0.51) | — | |
| SCHEMBL2089720 | 0.80 | PARP10 (0.50) | PARP10PARP15ACACBPARP2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323988-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | Wyeth LLC (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010009290-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2009091832-A1 | SYNTHESIS OF PYRAZOLES | WYETH (US) | 2009-07-23 | — | — | WO | disclosed |