Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | PDE2A | O00408 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24061603 | 0.79 | PDE2A (0.39) | SLC6A4PDE2AS1PR1HTR2AIDO1 | |
| SCHEMBL14131082 | 0.76 | FFAR4 (0.43) | SLC6A2SLC6A4PDE2AKCNH2TMEM97 | |
| SCHEMBL3678271 | 0.76 | IDO1 (0.37) | PDE2AIDO1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL30233883 | 0.75 | CYP1A1 (0.43) | PDE2ASCN10ABACE1KDM4E | |
| SCHEMBL25026056 | 0.75 | CYP1A1 (0.43) | PDE2ASCN10ABACE1KDM4E | |
| SCHEMBL28173592 | 0.74 | SLC6A4 (0.51) | SLC6A2SLC6A4PDE2ASLC6A3HTR2A | |
| SCHEMBL18570695 | 0.74 | CSNK1D (0.38) | SLC6A2SLC6A4PDE2AIDO1CYP2D6 | |
| SCHEMBL20344484 | 0.72 | RXFP1 (0.36) | SLC6A2SLC6A4ALDH1A1KCNH2TMEM97 | |
| SCHEMBL4263679 | 0.72 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3HTR2BALDH1A1 | |
| SCHEMBL15067318 | 0.71 | ACP1 (0.38) | IDO1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |