Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980298 | 0.77 | MAPK1 (0.38) | MAPK1MAPTKCNH2TMEM97SLC6A4 | |
| SCHEMBL23188990 | 0.74 | TSHR (0.38) | MAPK1MAPTNPSR1SLC6A2SLC6A4 | |
| SCHEMBL14131082 | 0.73 | FFAR4 (0.43) | KCNH2TMEM97SLC6A2SLC6A4MEN1 | |
| SCHEMBL20344524 | 0.73 | KIF11 (0.40) | MAPK1MAPTKCNH2SLC6A4MEN1 | |
| SCHEMBL18570980 | 0.72 | SLC6A2 (0.39) | KCNH2TMEM97SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL28173592 | 0.71 | SLC6A4 (0.51) | SLC6A2SLC6A4TRPV1CETPGAA | |
| SCHEMBL10238280 | 0.69 | ALDH1A1 (0.50) | RXFP1MAPTMEN1KMT2ACA1 | |
| SCHEMBL21885675 | 0.69 | RXFP1 (0.43) | RXFP1MAPK1MAPTNPSR1MEN1 | |
| SCHEMBL29643387 | 0.69 | RXFP1 (0.43) | RXFP1MAPK1MAPTNPSR1MEN1 | |
| SCHEMBL24576209 | 0.69 | RXFP1 (0.40) | RXFP1MAPK1MAPTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |