Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 15/20 | 0.54 |
| ▸ | METTL3 | Q86U44 | 11/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25949948 | 0.89 | PRMT5 (0.45) | PRMT5METTL3WDR77 | |
| SCHEMBL23892665 | 0.89 | PRMT5 (0.56) | PRMT5METTL3WDR77 | |
| SCHEMBL18572928 | 0.89 | PRMT5 (0.56) | PRMT5METTL3WDR77 | |
| SCHEMBL23892475 | 0.88 | PRMT5 (0.55) | PRMT5METTL3WDR77 | |
| SCHEMBL18572054 | 0.88 | PRMT5 (0.53) | PRMT5METTL3WDR77 | |
| SCHEMBL23892612 | 0.88 | METTL3 (0.53) | PRMT5METTL3WDR77 | |
| SCHEMBL23892669 | 0.88 | METTL3 (0.53) | PRMT5METTL3WDR77 | |
| SCHEMBL18572102 | 0.88 | PRMT5 (0.53) | PRMT5METTL3WDR77 | |
| SCHEMBL18572387 | 0.88 | PRMT5 (0.45) | PRMT5METTL3WDR77 | |
| SCHEMBL23892231 | 0.88 | PRMT5 (0.56) | PRMT5METTL3WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |