Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.53 |
| ▸ | METTL3 | Q86U44 | 9/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572083 | 1.00 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL18572089 | 0.93 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL18572066 | 0.93 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL18572002 | 0.91 | METTL3 (0.52) | PRMT5WDR77METTL3 | |
| SCHEMBL18572086 | 0.88 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL18572070 | 0.88 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL18571762 | 0.88 | PRMT5 (0.61) | PRMT5WDR77METTL3 | |
| SCHEMBL18571749 | 0.86 | PRMT5 (0.66) | PRMT5WDR77METTL3 | |
| SCHEMBL18572251 | 0.84 | METTL3 (0.71) | PRMT5WDR77METTL3 | |
| SCHEMBL18572256 | 0.84 | METTL3 (0.71) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |