Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.49 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571757 | 1.00 | PRMT5 (0.49) | PRMT5WDR77METTL3PI4KAPI4K2B | |
| SCHEMBL18572045 | 0.94 | METTL3 (0.55) | PRMT5WDR77METTL3 | |
| SCHEMBL18572878 | 0.92 | METTL3 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL18571590 | 0.91 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL25955020 | 0.91 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL18571774 | 0.91 | PRMT5 (0.50) | PRMT5WDR77METTL3 | |
| SCHEMBL18571507 | 0.91 | METTL3 (0.50) | PRMT5WDR77METTL3 | |
| SCHEMBL18572324 | 0.88 | METTL3 (0.44) | PRMT5WDR77METTL3 | |
| SCHEMBL22002083 | 0.87 | METTL3 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL18572882 | 0.87 | METTL3 (0.42) | PRMT5WDR77METTL3PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |