Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 12/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 5/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL989021 | 1.00 | SLC6A9 (0.48) | SLC6A9CYP3A4KDM1AJAK1NR3C2 | |
| SCHEMBL8017098 | 0.93 | SLC6A9 (0.52) | SLC6A9CYP3A4JAK1 | |
| Trifluoroacetic Acid SCHEMBL989183 | 0.91 | SLC6A9 (0.38) | SLC6A9CYP3A4KDM1AJAK1 | |
| SCHEMBL12096077 | 0.83 | SLC6A9 (0.41) | SLC6A9CYP3A4JAK1 | |
| SCHEMBL1857698 | 0.81 | SLC6A9 (0.41) | SLC6A9CYP3A4 | |
| SCHEMBL8029655 | 0.81 | SLC6A9 (0.72) | SLC6A9CYP3A4 | |
| Hydrochloric Acid SCHEMBL990317 | 0.80 | SLC6A9 (0.71) | SLC6A9CYP3A4 | |
| SCHEMBL1862538 | 0.79 | SLC6A9 (0.47) | SLC6A9CYP3A4 | |
| SCHEMBL12096179 | 0.76 | SLC6A9 (0.72) | SLC6A9CYP3A4KDM1AJAK1 | |
| Hydrochloric Acid SCHEMBL1858376 | 0.76 | SLC6A9 (0.71) | SLC6A9CYP3A4KDM1AJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957089-B2 | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-02-17 | — | — | US | disclosed |
| US-8653100-B2 | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy | ABBVIE INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-20130203749-A1 | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy | ABBVIE INC. (US) | 2013-08-08 | — | — | US | disclosed |
| EP-2271625-B1 | TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBOTT GMBH & CO KG (DE) | 2012-09-12 | — | — | EP | disclosed |
| US-20110105502-A1 | TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | Abbott BmbH & Co. KG (DE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105502-A1 | TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | GOLT1B, SLC10A1, SUGT1 | SLC6A9 73/4885CYP3A4 328/4885KDM1A 2843/4885 |
| US-20130203749-A1 | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy | GOLT1B, SLC10A1, SUGT1 | SLC6A9 73/4885CYP3A4 328/4885KDM1A 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.