Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | THRA | P10827 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MIF | P14174 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24055239 | 0.88 | MAOB (0.52) | THRBTP53NPC1RAB9APTPN7 | |
| SCHEMBL18535420 | 0.87 | THRB (0.52) | THRBTP53NPC1RAB9AMEN1 | |
| SCHEMBL18535521 | 0.86 | THRB (0.47) | THRBTP53NPC1RAB9APTPN7 | |
| SCHEMBL9607678 | 0.85 | NPC1 (0.45) | THRBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL9607860 | 0.85 | NPC1 (0.54) | TP53NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18535502 | 0.84 | THRB (0.45) | THRBTP53NPC1RAB9ARXFP1 | |
| SCHEMBL24595691 | 0.83 | MAOB (0.45) | THRBTP53NPC1RAB9ARXFP1 | |
| SCHEMBL803185 | 0.82 | THRB (0.59) | THRBTP53NPC1RAB9AMEN1 | |
| SCHEMBL19499899 | 0.82 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2AMIF | |
| SCHEMBL18558998 | 0.81 | NPC1 (0.50) | THRBNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032442-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2017-03-02 | — | — | WO | disclosed |