Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.44 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63441 | 0.79 | FGFR1 (0.52) | MAPTALDH1A1RAB9AKMT2ANR4A1 | |
| SCHEMBL63300 | 0.75 | FGFR1 (0.51) | MAPTALDH1A1RAB9AKMT2ANR4A1 | |
| SCHEMBL64066 | 0.74 | FGFR1 (0.75) | FGFR1NTRK1RETPDGFRBMARK3 | |
| SCHEMBL1859932 | 0.74 | NPC1 (0.53) | MAPTRAB9AKMT2AF10NPC1 | |
| Hydrochloric Acid SCHEMBL64171 | 0.74 | FGFR1 (0.51) | MAPTALDH1A1RAB9AKMT2ANR4A1 | |
| SCHEMBL1535779 | 0.73 | CHRM3 (0.56) | MAPTALDH1A1KMT2AMAPKAPK2ADRB1 | |
| SCHEMBL62894 | 0.70 | FGFR1 (0.76) | MAPTALDH1A1RAB9AKMT2ANR4A1 | |
| SCHEMBL22495337 | 0.69 | MAPT (0.79) | MAPTALDH1A1RAB9AKMT2ANR4A1 | |
| SCHEMBL63445 | 0.68 | F10 (0.55) | RAB9AFGFR1NTRK1RETPDGFRB | |
| SCHEMBL64452 | 0.68 | SIRT2 (0.43) | MAPTALDH1A1RAB9AKMT2AFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-B1 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2011-05-25 | — | — | EP | disclosed |