Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | F10 | P00742 | 13/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63115 | 0.78 | NPC1 (0.52) | NPC1RAB9AF10MEN1KMT2A | |
| SCHEMBL1858385 | 0.74 | MAPT (0.44) | NPC1RAB9AF10KMT2AMAPT | |
| SCHEMBL31254451 | 0.71 | RAB9A (1.00) | NPC1RAB9AF10MEN1KMT2A | |
| SCHEMBL63340 | 0.68 | NPC1 (0.52) | NPC1RAB9AF10MEN1KMT2A | |
| SCHEMBL4435852 | 0.68 | KMT2A (0.43) | MEN1KMT2AHPGDTAAR1POLB | |
| SCHEMBL22495299 | 0.66 | RAB9A (0.90) | NPC1RAB9AF10MEN1KMT2A | |
| SCHEMBL18737213 | 0.66 | RAB9A (0.79) | NPC1RAB9AF10MEN1KMT2A | |
| SCHEMBL22495406 | 0.65 | RAB9A (0.77) | NPC1RAB9AF10MEN1KMT2A | |
| SCHEMBL30863559 | 0.65 | F10 (0.59) | NPC1RAB9AF10POLBKLKB1 | |
| SCHEMBL62764 | 0.65 | MAPT (0.51) | NPC1RAB9AF10MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-B1 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2011-05-25 | — | — | EP | disclosed |