Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18584529 | 0.98 | BRD4 (0.47) | BRD4BRD9KDM4EALDH1A1BRPF1 | |
| SCHEMBL29092189 | 0.89 | BRD4 (0.43) | BRD4BRD9KDM4EALDH1A1BRPF1 | |
| SCHEMBL20726642 | 0.81 | BRD4 (0.66) | BRD4BRD9KDM4EALDH1A1BRPF1 | |
| SCHEMBL18584991 | 0.79 | MAP2K1 (0.46) | BRD4BRD9KDM4EMAPK1MAP2K1 | |
| SCHEMBL4049110 | 0.77 | BRD4 (0.39) | BRD4BRD9KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL30647042 | 0.76 | BRD4 (0.36) | BRD4BRD9ALDH1A1BRPF1 | |
| SCHEMBL29896541 | 0.75 | BRD4 (0.41) | BRD4BRD9KDM4EMAPK1MAP2K1 | |
| SCHEMBL6439758 | 0.74 | BRD4 (0.45) | BRD4BRD9KDM4EALDH1A1BRPF1 | |
| SCHEMBL28861326 | 0.73 | BRD4 (0.44) | BRD4BRD9KDM4EALDH1A1BRPF1 | |
| SCHEMBL34469515 | 0.72 | BRD4 (0.40) | BRD4BRD9KDM4EALDH1A1BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137542-B | Pyridone dicarboxamides as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-108137541-B | Pyridone dicarboxamides for use as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2021-07-06 | — | — | CN | disclosed |
| US-10927080-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2021-02-23 | — | — | US | disclosed |
| EP-3359531-B1 | 2-OXO-1,2-DIHYDROPYRIDINE-3,5-DICARBOXAMIDE COMPOUNDS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-08-19 | — | — | EP | disclosed |
| US-10471050-B2 | 2-OXO-1,2-dihydropyridine-3,5-dicarboxamide compounds as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-11-12 | — | — | US | disclosed |
| US-10428026-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-10-01 | — | — | US | disclosed |
| US-10370356-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-08-06 | — | — | US | disclosed |
| US-20180280368-A1 | 2-OXO-1,2-DIHYDROPYRIDINE-3,5-DICARBOXAMIDE COMPOUNDS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2018-10-04 | — | — | US | disclosed |
| US-20180282301-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2018-10-04 | — | — | US | disclosed |
| US-20180258044-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-09-13 | — | — | US | disclosed |
| EP-3353162-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2018-08-01 | — | — | EP | disclosed |
| CN-108290866-A | 2- oxo -1,2- dihydropyridine -3,5- diformamide compounds as bromine structural domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2018-07-17 | — | — | CN | disclosed |
| EP-3344615-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No. 2) Limited (GB) | 2018-07-11 | — | — | EP | disclosed |
| CN-108137541-A | For being used as the pyridone diformamide of bromine structural domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-108137542-A | Pyridone diformamide as bromine structural domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2018-06-08 | — | — | CN | disclosed |
| WO-2017050714-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017037116-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370356-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | BRD4, BRD3, BRDT | BRD4 1/4885BRD9 13/4885KDM4E 426/4885 |
| US-10428026-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | BRD4, BRD3, BRDT | BRD4 1/4885BRD9 13/4885KDM4E 426/4885 |
| US-10471050-B2 | 2-OXO-1,2-dihydropyridine-3,5-dicarboxamide compounds as bromodomain inhibitors | BRD2, BRD4, BRD3 | BRD4 2/4885BRD9 9/4885KDM4E 1215/4885 |
| US-20180280368-A1 | 2-OXO-1,2-DIHYDROPYRIDINE-3,5-DICARBOXAMIDE COMPOUNDS AS BROMODOMAIN INHIBITORS | BRD2, BRD4, BRD3 | BRD4 2/4885BRD9 9/4885KDM4E 1215/4885 |
| US-20180282301-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRDT | BRD4 1/4885BRD9 13/4885KDM4E 426/4885 |
| US-20180258044-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRDT | BRD4 1/4885BRD9 13/4885KDM4E 426/4885 |
| US-10927080-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | BRD4, BRD3, BRDT | BRD4 1/4885BRD9 13/4885KDM4E 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.