Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18584635 | 0.89 | BRD4 (0.49) | BRD4BRD9MAPK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL18584529 | 0.87 | BRD4 (0.47) | BRD4BRD9MAPK1MEN1KMT2A | |
| SCHEMBL28590434 | 0.79 | BRD4 (0.50) | BRD4BRD9MEN1KMT2ARAB9A | |
| SCHEMBL18584991 | 0.76 | MAP2K1 (0.46) | BRD4BRD9MAPK1MEN1KMT2A | |
| SCHEMBL480606 | 0.76 | BRD4 (0.50) | BRD4BRD9 | |
| SCHEMBL2260637 | 0.74 | TTR (0.45) | KMT2AMAP2K1CREBBPKDM4EALDH1A1 | |
| SCHEMBL480184 | 0.74 | TTR (0.45) | BRD4BRD9MEN1KMT2ARAB9A | |
| SCHEMBL21383990 | 0.74 | LMNA (0.41) | BRD4BRD9MAPK1MEN1KMT2A | |
| SCHEMBL15228321 | 0.74 | TPMT (0.47) | BRD4BRD9MEN1KMT2ARAB9A | |
| SCHEMBL4049110 | 0.74 | BRD4 (0.39) | BRD4BRD9MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137542-B | Pyridone dicarboxamides as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2023-10-27 | — | — | CN | disclosed |