Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18584997 | 0.85 | CNR2 (0.43) | CNR2FAAHCNR1ABHD12BRD4 | |
| SCHEMBL29193494 | 0.69 | BRD4 (0.47) | CNR2THRBCNR1NPC1RAB9A | |
| SCHEMBL18617201 | 0.69 | BRD4 (0.72) | BRD4TP53LMNARXFP1 | |
| SCHEMBL3451548 | 0.69 | CNR2 (0.35) | CNR2FAAHCNR1ABHD12MAPT | |
| SCHEMBL18584781 | 0.68 | BRD4 (0.66) | CNR2CNR1NPC1RAB9ANOD2 | |
| SCHEMBL18617246 | 0.67 | BRD4 (0.67) | THRBKDM4EMAPTBRD4TP53 | |
| SCHEMBL15207644 | 0.66 | LMNA (0.43) | CNR2THRBNPC1RAB9ANOD2 | |
| SCHEMBL17546136 | 0.65 | MAPT (0.68) | THRBNPC1RAB9ANOD2KMT2A | |
| SCHEMBL8276906 | 0.65 | MAPT (0.68) | THRBNPC1RAB9ANOD2KMT2A | |
| SCHEMBL3924364 | 0.65 | LMNA (0.49) | CNR2THRBKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344615-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No. 2) Limited (GB) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017037116-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-09 | — | — | WO | disclosed |