Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 8/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.72 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18585451 | 0.90 | HDAC6 (0.82) | HDAC6HDAC1HDAC3HDAC10HDAC2 | |
| SCHEMBL18585376 | 0.81 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC10HDAC2 | |
| SCHEMBL18619856 | 0.79 | HDAC6 (0.65) | HDAC6HDAC1HDAC3HDAC10HDAC2 | |
| SCHEMBL21661941 | 0.79 | HDAC6 (0.63) | HDAC6HDAC1HDAC3HDAC8LMNA | |
| SCHEMBL1932723 | 0.79 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC10HDAC2 | |
| SCHEMBL18585040 | 0.79 | HDAC6 (0.65) | HDAC6HDAC1HDAC3HDAC10HDAC2 | |
| SCHEMBL28192538 | 0.77 | HDAC1 (0.65) | HDAC6HDAC1HDAC3HDAC10HDAC2 | |
| SCHEMBL18585378 | 0.76 | HDAC1 (0.67) | HDAC6HDAC1HDAC3HDAC10HDAC2 | |
| SCHEMBL22919091 | 0.75 | HDAC1 (0.59) | HDAC6HDAC1HDAC3HDAC10HDAC2 | |
| SCHEMBL23898954 | 0.74 | HDAC1 (0.59) | HDAC6HDAC1MAPTALDH1A1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739064-B2 | HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739064-B2 | HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-08-29 | — | — | US | disclosed |
| US-20210139438-A1 | HDAC Inhibitors and Therapeutic Methods Using the Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-05-13 | — | — | US | disclosed |
| US-20210139438-A1 | HDAC Inhibitors and Therapeutic Methods Using the Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-05-13 | — | — | US | disclosed |
| US-10836733-B2 | HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-11-17 | — | — | US | disclosed |
| US-10836733-B2 | HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-11-17 | — | — | US | disclosed |
| US-20190023670-A1 | HDAC Inhibitors and Therapeutic Methods Using the Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-24 | — | — | US | disclosed |
| US-20190023670-A1 | HDAC Inhibitors and Therapeutic Methods Using the Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-24 | — | — | US | disclosed |
| WO-2017040564-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-03-09 | — | — | WO | disclosed |
| WO-2017040564-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190023670-A1 | HDAC Inhibitors and Therapeutic Methods Using the Same | HDAC1, HDAC9, HDAC8 | HDAC6 9/4885HDAC1 1/4885HDAC3 10/4885 |
| US-20210139438-A1 | HDAC Inhibitors and Therapeutic Methods Using the Same | HDAC1, HDAC9, HDAC8 | HDAC6 9/4885HDAC1 1/4885HDAC3 10/4885 |
| US-11739064-B2 | HDAC inhibitors and therapeutic methods using the same | HDAC1, HDAC9, HDAC8 | HDAC6 9/4885HDAC1 1/4885HDAC3 10/4885 |
| US-10836733-B2 | HDAC inhibitors and therapeutic methods using the same | HDAC1, HDAC9, HDAC8 | HDAC6 9/4885HDAC1 1/4885HDAC3 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.