Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.52 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | MMP12 | P39900 | 2/20 | 0.52 |
| ▸ | MMP14 | P50281 | 2/20 | 0.52 |
| ▸ | MMP15 | P51511 | 2/20 | 0.52 |
| ▸ | MMP16 | P51512 | 2/20 | 0.52 |
| ▸ | MMP26 | Q9NRE1 | 2/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18587613 | 1.00 | MMP1 (0.52) | MMP1MMP2MMP7MMP9MMP12 | |
| SCHEMBL3394741 | 0.82 | MMP1 (0.70) | MMP1MMP2MMP7MMP9MMP12 | |
| SCHEMBL3392159 | 0.82 | MMP1 (0.70) | MMP1MMP2MMP7MMP9MMP12 | |
| SCHEMBL3397104 | 0.82 | MMP1 (0.70) | MMP1MMP2MMP7MMP9MMP12 | |
| SCHEMBL3393324 | 0.82 | MMP1 (0.70) | MMP1MMP2MMP7MMP9MMP12 | |
| SCHEMBL3807794 | 0.80 | HRH3 (0.58) | MMP1MMP2MMP7MMP9MMP12 | |
| SCHEMBL3422815 | 0.78 | MAOB (0.54) | MMP1MMP2MMP7MMP9MMP12 | |
| SCHEMBL3422819 | 0.78 | MAOB (0.54) | MMP1MMP2MMP7MMP9MMP12 | |
| SCHEMBL3397537 | 0.77 | GRIN1 (0.66) | GRIN1GRIN2BHRH3 | |
| SCHEMBL13069934 | 0.77 | GRIN1 (0.66) | GRIN1GRIN2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344257-A1 | NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES | Westfälische Wilhelms-Universität Münster (DE) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017036880-A1 | NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES | Westfälische Wilhelms-Universität Münster (DE) | 2017-03-09 | — | — | WO | disclosed |