Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18585619 | 0.97 | TLR8 (0.52) | TLR8TLR7 | |
| SCHEMBL18587589 | 0.94 | TLR8 (0.48) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL18587595 | 0.91 | TLR8 (0.46) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL5508094 | 0.87 | TLR8 (0.41) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL20624057 | 0.86 | TLR8 (0.40) | TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL5504623 | 0.86 | TLR8 (0.40) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL18588106 | 0.86 | TLR8 (0.42) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL24409504 | 0.85 | TLR8 (0.40) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL18587114 | 0.84 | TLR8 (0.46) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL21976788 | 0.84 | TLR8 (0.39) | TLR8TLR7CSNK1A1CSNK1DPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344622-A1 | GUANIDINE SUBSTITUTED IMIDAZO[4,5-c]RING COMPOUNDS | 3M Innovative Properties Company (US) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017040233-A1 | GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |