SCHEMBL18590

SCHEMBL18590

Oc1cc(C(F)(F)F)ncn1

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.56
CHKA P35790 1/20 0.56
TRPV4 Q9HBA0 1/20 0.37
LOXL2 Q9Y4K0 2/20 0.35
LOX P28300 1/20 0.34
MAP4K4 O95819 1/20 0.31
SMARCA2 P51531 1/20 0.31
SMARCA4 P51532 1/20 0.31
AR P10275 1/20 0.30
NOTUM Q6P988 1/20 0.30
IDO1 P14902 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL27848615 0.96 CA2 (0.52) CA2CHKATRPV4LOXL2LOX
Cyclopropane SCHEMBL27848616 0.94 CA2 (0.50) CA2CHKATRPV4LOXL2LOX
SCHEMBL8167991 0.84 CA2 (0.39) CA2CHKA
SCHEMBL8175868 0.82 CA2 (0.38) CA2CHKA
SCHEMBL602858 0.82 CA2 (0.38) CA2CHKA
SCHEMBL27264896 0.82 CA2 (0.68) CA2CHKATRPV4LOXL2LOX
SCHEMBL601141 0.79 CA2 (0.35) CA2CHKA
SCHEMBL2627819 0.76 SMN1; SMN2 (0.33) CA2CHKA
SCHEMBL31254070 0.76
SCHEMBL18861976 0.73 CA2 (0.47) CA2CHKASMARCA2SMARCA4AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240154124-A1 NEGATIVE ELECTRODE PLATE AND LITHIUM-ION BATTERY COMPRISING SAME ZHUHAI COSMX BATTERY CO., LTD. (CN) 2024-05-09 US claimed
CN-115124475-B Pyrimidine derivative and preparation method and application thereof 贵阳学院 2023-11-10 CN claimed
CN-115124475-A Pyrimidine derivative and preparation method and application thereof 贵阳学院 2022-09-30 CN claimed
CN-106188013-A A kind of synthetic method of 6 trifluoromethyl N (2 trifluoro methyl indole 5 base) methyl 4 pyrimidinamine 中国药科大学 2016-12-07 CN claimed
CN-102887860-B Preparation method of 4-chloro-6-trifluoromethylpyrimidine type compound SHANGHAI TITAN TECHNOLOGY CO LTD 2015-07-01 CN claimed
CN-102887860-A Preparation method of 4-chloro-6-trifluoromethylpyrimidine type compound SHANGHAI TITAN TECHNOLOGY CO LTD 2013-01-23 CN claimed
EP-0395977-A1 Process for the preparation of 4-hydroxy-6-polyfluoroalkylpyrimidines LONZA AG (CH) 1990-11-07 EP claimed
EP-0224217-B1 PHOSPHORIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR COMBATTING PESTS BASF Aktiengesellschaft (DE) 1989-06-21 EP claimed
EP-0224217-A1 Phosphoric acid derivatives, process for their preparation and their use for combatting pests BASF Aktiengesellschaft (DE) 1987-06-03 EP claimed
CN-117126147-B Pyrimidine substituted 1,3, 4-oxadiazole derivative, preparation method and application 贵阳学院 2026-05-15 CN disclosed
US-12471596-B2 Substituted 6-membered heteroaryl piperidinyl ethanones PI INDUSTRIES LTD. (IN) 2025-11-18 US disclosed
WO-2025102293-A1 NEUROACTIVE ANDROGEN RECEPTOR MODULATOR AND USE THEREOF 北京脑科学与类脑研究所 2025-05-22 WO disclosed
CN-114761403-B 1- (4- (4- (5-Phenyl-4, 5-dihydro-isoxazol-3-yl) thiazol-2-yl) piperidin-1-yl) -ethan-1-one derivatives and related compounds as crop protection fungicides PI工业有限公司 2024-08-27 CN disclosed
CN-118251381-A Deuterated (trifluoromethyl) pyrimidin-2-amine compounds as enhancers of HMRGX's 1 receptor 伊莱利利公司 2024-06-25 CN disclosed
US-5314892-A Fungicidal pyrimidinyloxyphenyl-3-methoxy propenoates IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1994-05-24 US disclosed
US-5179098-A Substituted, methoxypropenoate pyrimidines, plants IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-01-12 US disclosed
EP-0430471-A1 Fungicides ZENECA LIMITED (GB) 1991-06-05 EP disclosed
EP-0395977-A1 Process for the preparation of 4-hydroxy-6-polyfluoroalkylpyrimidines LONZA AG (CH) 1990-11-07 EP disclosed
EP-0224217-B1 PHOSPHORIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR COMBATTING PESTS BASF Aktiengesellschaft (DE) 1989-06-21 EP disclosed
EP-0224217-A1 Phosphoric acid derivatives, process for their preparation and their use for combatting pests BASF Aktiengesellschaft (DE) 1987-06-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12471596-B2 Substituted 6-membered heteroaryl piperidinyl ethanones CCNK, CCNA1, CYP1A1 CA2 4518/4885CHKA 873/4885TRPV4 3955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.