Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 11/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185551 | 0.91 | CNR2 (0.33) | CNR2TRPV1FAAH | |
| SCHEMBL186053 | 0.91 | CNR2 (0.34) | CNR2TRPV1TP53FAAHCNR1 | |
| SCHEMBL2805925 | 0.91 | CNR2 (0.37) | CNR2P2RX7TP53CNR1CYP1A2 | |
| SCHEMBL186188 | 0.89 | CNR2 (0.35) | CNR2TRPV1P2RX7TP53FAAH | |
| SCHEMBL186992 | 0.89 | CNR2 (0.33) | CNR2TRPV1P2RX7TP53FAAH | |
| SCHEMBL14856668 | 0.85 | CNR2 (0.36) | CNR2TRPV1P2RX7FAAHCYP1A2 | |
| SCHEMBL185518 | 0.85 | OPRL1 (0.37) | CNR2TRPV1P2RX7FAAH | |
| SCHEMBL14856869 | 0.84 | BDKRB1 (0.37) | CNR2TRPV1 | |
| SCHEMBL185881 | 0.84 | OPRL1 (0.37) | CNR2TRPV1P2RX7FAAH | |
| SCHEMBL14856721 | 0.84 | CNR2 (0.38) | CNR2TRPV1P2RX7FAAHCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |