Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186188 | 0.94 | CNR2 (0.35) | CNR2TP53P2RX7CYP1A2FAAH | |
| SCHEMBL185729 | 0.92 | CNR2 (0.35) | CNR2TP53P2RX7POLBMAPT | |
| SCHEMBL14856646 | 0.91 | CNR2 (0.35) | CNR2TP53P2RX7BDKRB1 | |
| SCHEMBL2809124 | 0.91 | CNR2 (0.36) | CNR2TP53P2RX7BDKRB1POLB | |
| SCHEMBL186543 | 0.90 | OPRL1 (0.34) | CNR2P2RX7BDKRB1FAAHTRPV1 | |
| SCHEMBL185940 | 0.89 | CNR2 (0.34) | CNR2TP53P2RX7CYP1A2FAAH | |
| SCHEMBL186053 | 0.89 | CNR2 (0.34) | CNR2TP53BDKRB1POLBCYP1A2 | |
| SCHEMBL186281 | 0.87 | OPRL1 (0.36) | CNR2P2RX7FAAHTRPV1 | |
| Hydrochloric Acid SCHEMBL185917 | 0.86 | FAAH (0.32) | FAAHTRPV1 | |
| SCHEMBL186076 | 0.86 | CNR2 (0.37) | CNR2TP53P2RX7MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |