Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SHBG | P04278 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28222611 | 0.94 | HTT (0.38) | HTTUSP2SMN1; SMN2TP53HPGD | |
| SCHEMBL4372558 | 0.82 | PDE8B (0.36) | USP2SMN1; SMN2TP53HPGDALOX12 | |
| SCHEMBL18833108 | 0.82 | NOS1 (0.36) | HTTUSP2SMN1; SMN2TP53HPGD | |
| SCHEMBL12090067 | 0.81 | PDE8B (0.36) | HTTUSP2SMN1; SMN2TP53HPGD | |
| SCHEMBL8860611 | 0.81 | PDE8B (0.36) | HTTUSP2SMN1; SMN2TP53HPGD | |
| SCHEMBL12089502 | 0.81 | PDE8B (0.36) | HTTUSP2SMN1; SMN2TP53HPGD | |
| SCHEMBL17937254 | 0.79 | TP53 (0.33) | USP2SMN1; SMN2TP53HPGDALOX12 | |
| SCHEMBL797696 | 0.79 | PDE8B (0.35) | HTTUSP2SMN1; SMN2TP53HPGD | |
| SCHEMBL13502926 | 0.78 | ANPEP (0.34) | HTTUSP2SMN1; SMN2TP53HPGD | |
| SCHEMBL10379970 | 0.78 | USP2 (0.35) | HTTUSP2SMN1; SMN2TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47267-E1 | Pyridinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2019-03-05 | — | — | US | disclosed |
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |