Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.45 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 4/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19257549 | 0.87 | SLC22A12 (0.42) | SLC22A12CYP3A4CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL17996191 | 0.84 | NR3C2 (0.44) | SLC22A12CYP3A4CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL23562644 | 0.79 | SLC22A12 (0.47) | SLC22A12CYP3A4CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL12266458 | 0.78 | PIK3CB (0.51) | SLC22A12CYP3A4CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL22928261 | 0.78 | CYP3A4 (0.48) | CYP3A4CYP2C9ALDH1A1LRRK2 | |
| SCHEMBL19728984 | 0.77 | SLC22A12 (0.38) | SLC22A12CYP3A4CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL30137071 | 0.77 | SLC22A12 (0.55) | SLC22A12CYP3A4CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL18595668 | 0.75 | CYP17A1 (0.39) | CYP17A1PGRALDH1A1POLBHTT | |
| SCHEMBL18595671 | 0.74 | CYP17A1 (0.41) | CYP17A1ALDH1A1POLBHTTCTSS | |
| SCHEMBL19728973 | 0.74 | ALDH1A1 (0.45) | SLC22A12CYP3A4CYP2C9SLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10596184-B2 | Aza-heteroaryl compounds as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2020-03-24 | — | — | US | disclosed |
| US-9586949-B2 | Aza-heteroaryl compounds as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2017-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10596184-B2 | Aza-heteroaryl compounds as PI3K-gamma inhibitors | PIK3R5, PIK3R1, PIK3R3 | SLC22A12 3665/4885CYP3A4 1392/4885CYP2C9 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.