Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TRPV3 | Q8NET8 | 12/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758 | 0.82 | MAPT (0.55) | MAPTTRPV1 | |
| SCHEMBL1732 | 0.69 | LMNA (0.40) | MAPTLMNA | |
| SCHEMBL6682 | 0.69 | LPAR1 (0.50) | MAPT | |
| SCHEMBL1733 | 0.67 | LPAR1 (0.37) | MAPTLMNA | |
| SCHEMBL343557 | 0.66 | LPAR1 (0.66) | MAPTTRPV1 | |
| SCHEMBL6551 | 0.65 | MAPT (0.47) | MAPT | |
| SCHEMBL343498 | 0.65 | LPAR1 (0.64) | MAPTLMNA | |
| SCHEMBL4406 | 0.65 | SMPD1 (0.44) | MAPT | |
| SCHEMBL18252797 | 0.65 | IDO1 (0.49) | MAPTTRPV3LMNA | |
| SCHEMBL2635566 | 0.65 | MAPT (0.52) | MAPTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |