Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.37 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.37 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18167225 | 0.92 | MMP12 (0.37) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6860 | 0.89 | LPAR1 (0.40) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7142 | 0.87 | GAA (0.40) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7310 | 0.87 | LPAR1 (0.39) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL3677 | 0.86 | LPAR1 (0.38) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL1596 | 0.86 | LPAR1 (0.52) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18597787 | 0.86 | LPAR1 (0.37) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18597808 | 0.85 | LPAR1 (0.39) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6481 | 0.85 | GAA (0.39) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4185 | 0.84 | GAA (0.38) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |