Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 17/20 | 0.56 |
| ▸ | ACE | P12821 | 11/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14900520 | 1.00 | MME (0.56) | MMEACEMMP2MMP3PPARG | |
| SCHEMBL14900634 | 0.84 | MME (0.78) | MMEACEPPARGPPARA | |
| SCHEMBL14890541 | 0.80 | MME (0.74) | MMEACE | |
| SCHEMBL18598046 | 0.80 | MME (0.74) | MMEACE | |
| SCHEMBL14902382 | 0.77 | MME (0.50) | MMEACE | |
| SCHEMBL14891213 | 0.76 | MME (0.73) | MMEACE | |
| SCHEMBL14891459 | 0.73 | MME (1.00) | MMEACE | |
| SCHEMBL18597892 | 0.72 | MME (0.48) | MMEPPARGPPARA | |
| SCHEMBL14890510 | 0.72 | MME (0.48) | MMEPPARGPPARA | |
| SCHEMBL14891228 | 0.71 | MME (1.00) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-B1 | OXALIC ACID AMIDES AS NEPRILYSIN INHIBITORS, PHARMACEUTICAL COMPOSITION THEREOF AND PREPARATION THEREOF | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-03-08 | — | — | EP | disclosed |