Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 15/20 | 0.72 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.72 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.72 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.72 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.72 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5994 | 1.00 | LPAR1 (0.72) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7035 | 0.89 | LPAR1 (0.61) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18597685 | 0.89 | LPAR1 (0.61) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| Bms-986020 SCHEMBL343068 | 0.84 | LPAR1 (1.00) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| Bms-986020 SCHEMBL14590 | 0.84 | LPAR1 (1.00) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| Bms-986020 SCHEMBL344742 | 0.84 | LPAR1 (1.00) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL14405 | 0.83 | LPAR1 (0.60) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7331 | 0.83 | LPAR1 (0.70) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18597805 | 0.83 | LPAR1 (0.70) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL22257227 | 0.83 | LPAR1 (0.98) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |