Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 10/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | BCL2 | P10415 | 5/20 | 0.53 |
| ▸ | BCL2L2 | Q92843 | 5/20 | 0.53 |
| ▸ | BAD | Q92934 | 5/20 | 0.53 |
| ▸ | MME | P08473 | 2/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19425333 | 0.89 | MAPT (0.61) | DUSP3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL19425506 | 0.87 | DUSP3 (0.71) | DUSP3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL26458902 | 0.76 | MAPT (1.00) | DUSP3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14680220 | 0.76 | MAPT (1.00) | DUSP3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL19425501 | 0.74 | DUSP3 (0.72) | DUSP3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL19430434 | 0.74 | MAPT (1.00) | DUSP3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13894970 | 0.73 | DUSP3 (0.71) | DUSP3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14680251 | 0.71 | MAPT (0.78) | DUSP3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13846498 | 0.70 | MAPT (0.87) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL4568729 | 0.69 | MAPT (0.80) | DUSP3MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138838-A1 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | Dana-Farber Cancer Institute, Inc. (US) | 2017-03-08 | — | — | EP | disclosed |