Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.50 |
| ▸ | KDR | P35968 | 14/20 | 0.50 |
| ▸ | EGFR | P00533 | 14/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.50 |
| ▸ | PRKDC | P78527 | 14/20 | 0.50 |
| ▸ | ABL1 | P00519 | 13/20 | 0.50 |
| ▸ | HCK | P08631 | 13/20 | 0.50 |
| ▸ | MTOR | P42345 | 13/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.50 |
| ▸ | RET | P07949 | 4/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19565379 | 1.00 | SRC (0.50) | SRCKDREGFRPIK3CDPIK3CA | |
| SCHEMBL24251925 | 0.92 | SRC (0.57) | SRCKDREGFRPIK3CDPIK3CA | |
| SCHEMBL18426277 | 0.87 | JAK2 (0.54) | SRCKDREGFRPIK3CDPIK3CA | |
| SCHEMBL17779748 | 0.87 | JAK2 (0.54) | SRCKDREGFRPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL18426627 | 0.86 | JAK2 (0.53) | SRCKDREGFRPIK3CDPIK3CA | |
| SCHEMBL13860277 | 0.86 | SRC (0.62) | SRCKDREGFRPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL18426628 | 0.86 | JAK2 (0.53) | SRCKDREGFRPIK3CDPIK3CA | |
| SCHEMBL4826019 | 0.86 | SRC (0.62) | SRCKDREGFRPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL17911530 | 0.85 | SRC (0.60) | SRCKDREGFRPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL17770592 | 0.85 | SRC (0.60) | SRCKDREGFRPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138842-B1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS | ZHEJIANG DTRM BIOPHARMA CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3138842-A1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS | Zhejiang DTRM Biopharma Co., Ltd. (CN) | 2017-03-08 | — | — | EP | disclosed |