Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5151638 | 0.86 | ALDH1A1 (0.47) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL31163394 | 0.86 | ALDH1A1 (0.47) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL9921728 | 0.84 | HSD17B10 (0.48) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL19062169 | 0.84 | HSD17B10 (0.48) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL4705983 | 0.82 | ALDH1A1 (0.54) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL9918218 | 0.82 | CYP3A4 (0.50) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL19592361 | 0.81 | ALDH1A1 (0.47) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL19592362 | 0.79 | HSD17B10 (0.46) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL17107060 | 0.78 | HSD17B10 (0.50) | ALDH1A1POLBNR4A1RAB9AHSD17B10 | |
| SCHEMBL4362389 | 0.77 | ALDH1A1 (0.59) | ALDH1A1POLBNR4A1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |