Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5070254 | 1.00 | TSHR (0.35) | TSHRLMNATHRBFDPSCES2 | |
| SCHEMBL8895789 | 0.94 | TSHR (0.37) | TSHRTHRBFDPSCES2LPAR1 | |
| SCHEMBL7177286 | 0.94 | TSHR (0.35) | TSHRLMNATHRBFDPSESR1 | |
| SCHEMBL5892589 | 0.94 | TSHR (0.40) | TSHRLMNATHRBFDPSCES2 | |
| SCHEMBL23666384 | 0.90 | — | — | |
| SCHEMBL5898104 | 0.87 | — | — | |
| SCHEMBL10930115 | 0.87 | TSHR (0.40) | TSHRLMNATHRBFDPSCES2 | |
| SCHEMBL16286664 | 0.87 | TSHR (0.40) | TSHRLMNATHRBFDPSESR1 | |
| SCHEMBL208096 | 0.87 | TSHR (0.40) | TSHRLMNATHRBFDPSESR1 | |
| SCHEMBL9248668 | 0.87 | TSHR (0.33) | TSHRFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4180427-A1 | COMPOUND CAPABLE OF INHIBITING AND DEGRADING ANDROGEN RECEPTORS, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICAL USES THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2023-05-17 | — | — | EP | disclosed |
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |