Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187250 | 0.91 | TRPV1 (0.41) | MAPTALDH1A1LMNAGAATRPV1 | |
| SCHEMBL186236 | 0.90 | TRPV1 (0.39) | MAPTALDH1A1LMNAGAATRPV1 | |
| SCHEMBL186795 | 0.89 | TRPV1 (0.39) | MAPTLMNATRPV1MAPK1NAMPT | |
| SCHEMBL186121 | 0.88 | TRPV1 (0.42) | MAPTALDH1A1TRPV1MEN1KMT2A | |
| SCHEMBL185519 | 0.88 | TRPV1 (0.39) | TRPV1MAPK1NAMPTLIMK1LIMK2 | |
| SCHEMBL300628 | 0.87 | TRPV1 (0.39) | TRPV1MAPK1NAMPTCNR1LIMK1 | |
| SCHEMBL186522 | 0.87 | PDE10A (0.38) | MAPTALDH1A1LMNATRPV1MAPK1 | |
| SCHEMBL186303 | 0.86 | ALDH1A1 (0.42) | MAPTALDH1A1LMNAMAPK1MEN1 | |
| SCHEMBL186423 | 0.86 | TRPV1 (0.37) | TRPV1MAPK1NAMPTLIMK1LIMK2 | |
| SCHEMBL186908 | 0.86 | TRPV1 (0.42) | MAPTTRPV1MAPK1NAMPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297148-B8 | NOVEL DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALCANONE AND USE THEREOF AS P75 INHIBITORS | SANOFI SA (FR) | 2012-03-28 | — | — | EP | disclosed |
| EP-2297148-B1 | NOVEL DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALCANONE AND USE THEREOF AS P75 INHIBITORS | SANOFI SA (FR) | 2012-01-04 | — | — | EP | disclosed |
| EP-2297148-A1 | NOVEL DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALCANONE AND USE THEREOF AS P75 INHIBITORS | Sanofi-Aventis (FR) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009150388-A1 | NOVEL DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALCANONE AND USE THEREOF AS P75 INHIBITORS | SANOFI-AVENTIS (FR) | 2009-12-17 | — | — | WO | disclosed |