Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738900 | 0.90 | KMT2A (0.46) | KMT2ACYP1A2CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL30996203 | 0.89 | CYP1A2 (0.55) | KMT2ACYP1A2CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL6093583 | 0.86 | KMT2A (0.53) | KMT2ACYP1A2CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL10448669 | 0.84 | KMT2A (0.51) | KMT2ACYP1A2CYP2D6SMN1; SMN2HTT | |
| SCHEMBL22799247 | 0.84 | KMT2A (0.51) | KMT2ACYP1A2CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL8708894 | 0.83 | KMT2A (0.50) | KMT2ACYP1A2CYP2D6SMN1; SMN2HTT | |
| SCHEMBL9736812 | 0.83 | KMT2A (0.50) | KMT2ACYP1A2CYP2D6SMN1; SMN2HTT | |
| SCHEMBL8475420 | 0.83 | KMT2A (0.50) | KMT2ACYP1A2CYP2D6SMN1; SMN2HTT | |
| SCHEMBL9868831 | 0.83 | KMT2A (0.50) | KMT2ACYP1A2CYP2D6SMN1; SMN2HTT | |
| SCHEMBL19746373 | 0.83 | KMT2A (0.50) | KMT2ACYP1A2CYP2D6SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138841-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2017-03-08 | — | — | EP | disclosed |