Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | DRD5 | P21918 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL320153 | 0.92 | MEN1 (0.55) | HTR7DRD2DRD3DRD5HTR1A | |
| SCHEMBL318453 | 0.90 | MEN1 (0.58) | HTR7DRD2DRD3DRD5HTR1A | |
| SCHEMBL318473 | 0.87 | MEN1 (0.50) | HTR7DRD2DRD3DRD5HTR1A | |
| SCHEMBL318506 | 0.87 | HTR7 (0.48) | HTR7DRD2DRD3DRD5HTR1A | |
| SCHEMBL18601782 | 0.87 | HTR7 (0.48) | HTR7DRD2DRD3DRD5HTR1A | |
| SCHEMBL320041 | 0.87 | MEN1 (0.49) | DRD2DRD3MEN1TP53CYP1A2 | |
| SCHEMBL319846 | 0.85 | MEN1 (0.63) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318585 | 0.85 | MEN1 (0.53) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318803 | 0.82 | MEN1 (0.51) | DRD2DRD3MEN1TP53CYP1A2 | |
| SCHEMBL318770 | 0.82 | HTR7 (0.43) | HTR7DRD2DRD3DRD5HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138841-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2017-03-08 | — | — | EP | disclosed |