Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18602007 | 0.88 | P2RX7 (0.41) | HTR1AHTR7MEN1TP53CYP1A2 | |
| SCHEMBL318607 | 0.81 | MEN1 (0.49) | HTR1AHTR7MEN1TP53CYP1A2 | |
| SCHEMBL318993 | 0.80 | MEN1 (0.56) | HTR1AHTR7MEN1TP53CYP1A2 | |
| SCHEMBL18601842 | 0.79 | CYP1A2 (0.43) | HTR7MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL318732 | 0.78 | MEN1 (0.53) | HTR1AHTR7MEN1TP53CYP1A2 | |
| SCHEMBL10248483 | 0.76 | MEN1 (0.54) | HTR1AHTR7MEN1TP53CYP1A2 | |
| SCHEMBL319183 | 0.76 | MEN1 (0.47) | HTR1AHTR7MEN1TP53CYP1A2 | |
| SCHEMBL18601799 | 0.75 | P2RX7 (0.44) | HTR7MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL318646 | 0.70 | KCNH2 (0.51) | HTR1AHTR7MEN1TP53CYP1A2 | |
| SCHEMBL318643 | 0.69 | MEN1 (0.57) | MEN1TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138841-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2017-03-08 | — | — | EP | disclosed |