Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860198 | 1.00 | TGFBR1 (0.40) | TGFBR1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL1856736 | 0.83 | TGFBR1 (0.40) | TGFBR1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL1856738 | 0.83 | TGFBR1 (0.40) | TGFBR1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL3139920 | 0.82 | KDM4E (0.40) | TGFBR1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL3139908 | 0.82 | KDM4E (0.40) | TGFBR1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL1856967 | 0.81 | HDAC1 (0.47) | TGFBR1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL1856969 | 0.81 | HDAC1 (0.47) | TGFBR1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL1862525 | 0.81 | HDAC1 (0.45) | TGFBR1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL3146249 | 0.81 | EPHX2 (0.36) | TGFBR1HDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL1862527 | 0.81 | HDAC1 (0.45) | TGFBR1HDAC1HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868994-B1 | SULFONYLPYRROLES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2011-05-25 | — | — | EP | disclosed |
| US-20090117074-A1 | Sulfonylpyrroles as Histone Deacetylase Inhibitors | NYCOMED GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| EP-1868994-A1 | SULFONYLPYRROLES AS HISTONE DEACETYLASE INHIBITORS | Nycomed GmbH (DE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105979-A1 | SULFONYLPYRROLES AS HISTONE DEACETYLASE INHIBITORS | NYCOMED GMBH (DE) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090117074-A1 | Sulfonylpyrroles as Histone Deacetylase Inhibitors | HDAC1, HDAC3, HDAC2 | TGFBR1 2142/4885HDAC1 1/4885HDAC6 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.